Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 5/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.53 |
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | CCR3 | P51677 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4592063 | 0.87 | ALDH1A1 (0.54) | ACHEHRH3LTA4HFAAHKDM4E | |
| SCHEMBL22804324 | 0.84 | CCR3 (0.49) | ACHEHRH3CCR3 | |
| SCHEMBL13343789 | 0.84 | ACHE (0.55) | ACHEHRH3LTA4HALDH1A1SIGMAR1 | |
| SCHEMBL8825359 | 0.84 | ACHE (0.60) | ACHEHRH3 | |
| SCHEMBL368874 | 0.83 | CCR3 (0.67) | ACHELTA4HALDH1A1BCHECCR3 | |
| SCHEMBL20538760 | 0.81 | ACHE (0.52) | ACHEHRH3LTA4HBCHEOPRM1 | |
| SCHEMBL17030671 | 0.81 | MEN1 (0.56) | ACHEHRH3LTA4HKDM4EALDH1A1 | |
| SCHEMBL5418095 | 0.81 | CYP2D6 (0.57) | ACHEHRH3LTA4HFAAHKDM4E | |
| SCHEMBL9390500 | 0.80 | MAOB (0.62) | ACHEFAAHKDM4EALDH1A1MAOB | |
| SCHEMBL29201740 | 0.80 | ACHE (0.62) | ACHEHRH3FAAHSIGMAR1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113993872-B | EGFR inhibitors for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2024-09-24 | — | — | CN | disclosed |
| EP-3986896-A1 | EGFR INHIBITORS FOR THE TREATMENT OF CANCER | F. Hoffmann-La Roche AG (CH) | 2022-04-27 | — | — | EP | disclosed |
| CN-113993872-A | EGFR inhibitors for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2022-01-28 | — | — | CN | disclosed |
| WO-2020254572-A1 | EGFR INHIBITORS FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2020-12-24 | — | — | WO | disclosed |