Fluocinolone Acetonide

SCHEMBL22807167

CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)C(O)C[C@]2(C)[C@H]1C(=O)CO

nearest known ligand 0.73

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	9/20	0.73

▸	LMNA	P02545	7/20	0.73

▸	PGR	P06401	7/20	0.73

▸	HIF1A	Q16665	7/20	0.73

▸	CYP3A4	P08684	4/20	0.73

▸	NR1I2	O75469	3/20	0.73

▸	AR	P10275	3/20	0.73

▸	MAPT	P10636	2/20	0.73

▸	HSD17B10	Q99714	1/20	0.73

▸	TDP1	Q9NUW8	1/20	0.73

▸	KDM4E	B2RXH2	1/20	0.73

▸	MAPK1	P28482	1/20	0.73

▸	HTR2B	P41595	1/20	0.65

▸	ABCB11	O95342	1/20	0.65

▸	CHRM1	P11229	1/20	0.65

▸	SMN1; SMN2	Q16637	1/20	0.65

▸	ALDH1A1	P00352	1/20	0.61

▸	MEN1	O00255	1/20	0.61

▸	KMT2A	Q03164	1/20	0.61

▸	NPSR1	Q6W5P4	2/20	0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Triamcinolone Acetonide SCHEMBL7988975	0.98	NR3C1 (0.70)	NR3C1LMNAPGRHIF1ACYP3A4
Diflucortolone SCHEMBL13723891	0.88	HIF1A (0.85)	NR3C1LMNAPGRHIF1ACYP3A4
Diflucortolone SCHEMBL28142809	0.88	HIF1A (0.85)	NR3C1LMNAPGRHIF1ACYP3A4
Fluocinolone Acetonide SCHEMBL5501859	0.87	HIF1A (0.77)	NR3C1LMNAPGRHIF1ACYP3A4
Flumethasone SCHEMBL18011119	0.86	HIF1A (0.72)	NR3C1LMNAPGRHIF1ACYP3A4
Desonide SCHEMBL28118984	0.85	NR3C1 (0.70)	NR3C1LMNAPGRHIF1ACYP3A4
Desonide SCHEMBL992111	0.85	NR3C1 (0.70)	NR3C1LMNAPGRHIF1ACYP3A4
Fluocinolone Acetonide SCHEMBL15256220	0.85	NR3C1 (1.00)	NR3C1LMNAPGRHIF1ACYP3A4
Fluocinolone Acetonide SCHEMBL13046617	0.85	NR3C1 (1.00)	NR3C1LMNAPGRHIF1ACYP3A4
Fluocinolone Acetonide SCHEMBL21153661	0.85	NR3C1 (1.00)	NR3C1LMNAPGRHIF1ACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3986431-A1	COMPOSITIONS AND METHODS OF TREATING A TH2-MEDIATED CONDITION USING PREVOTELLA	Evelo Biosciences, Inc. (US)	2022-04-27	—	—	EP	disclosed
WO-2020257390-A1	COMPOSITIONS AND METHODS OF TREATING A TH2-MEDIATED CONDITION USING PREVOTELLA	EVELO BIOSCIENCES, INC. (US)	2020-12-24	—	—	WO	disclosed