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Triamcinolone Acetonide

Triamcinolone Acetonide

SCHEMBL7988975

CC(=O)O.CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Triamcinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 9/20 0.70
▸ LMNA P02545 7/20 0.70
▸ HIF1A Q16665 7/20 0.70
▸ PGR P06401 7/20 0.70
▸ CYP3A4 P08684 4/20 0.70
▸ NR1I2 O75469 3/20 0.70
▸ AR P10275 3/20 0.70
▸ MAPT P10636 2/20 0.70
▸ HSD17B10 Q99714 1/20 0.70
▸ TDP1 Q9NUW8 1/20 0.70
▸ KDM4E B2RXH2 1/20 0.70
▸ MAPK1 P28482 1/20 0.70
▸ HTR2B P41595 1/20 0.63
▸ ABCB11 O95342 1/20 0.63
▸ CHRM1 P11229 1/20 0.63
▸ SMN1; SMN2 Q16637 1/20 0.63
▸ ALDH1A1 P00352 1/20 0.61
▸ MEN1 O00255 1/20 0.61
▸ KMT2A Q03164 1/20 0.61
▸ NPSR1 Q6W5P4 2/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fluocinolone Acetonide SCHEMBL22807167 0.98 NR3C1 (0.73) NR3C1LMNAHIF1APGRCYP3A4
Triamcinolone Acetonide SCHEMBL15283872 0.86 HIF1A (0.95) NR3C1LMNAHIF1APGRCYP3A4
Diflucortolone SCHEMBL28142809 0.86 HIF1A (0.85) NR3C1LMNAHIF1APGRCYP3A4
Diflucortolone SCHEMBL13723891 0.86 HIF1A (0.85) NR3C1LMNAHIF1APGRCYP3A4
Fluocinolone Acetonide SCHEMBL5501859 0.86 HIF1A (0.77) NR3C1LMNAHIF1APGRCYP3A4
Flumethasone SCHEMBL18011119 0.84 HIF1A (0.72) NR3C1LMNAHIF1APGRCYP3A4
Desonide SCHEMBL992111 0.84 NR3C1 (0.70) NR3C1LMNAHIF1APGRCYP3A4
Desonide SCHEMBL28118984 0.84 NR3C1 (0.70) NR3C1LMNAHIF1APGRCYP3A4
Triamcinolone Acetonide SCHEMBL14782684 0.84 HIF1A (0.97) NR3C1LMNAHIF1APGRCYP3A4
Triamcinolone Acetonide SCHEMBL2229029 0.84 HIF1A (0.97) NR3C1LMNAHIF1APGRCYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0831912-A4 IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS OCULEX PHARM INC (US) 2000-08-30 — — EP disclosed
EP-0831912-A1 IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS OCULEX PHARMACEUTICALS, INC. (US) 1998-04-01 — — EP disclosed
WO-1996038174-A1 IMPROVED FORMULATION FOR CONTROLLED RELEASE OF DRUGS BY COMBINING HYDROPHILIC AND HYDROPHOBIC AGENTS OCULEX PHARMACEUTICALS, INC. (US) 1996-12-05 — — WO disclosed
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