Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluocinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 known ✓ | P04150 | 6/20 | 0.77 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.77 |
| ▸ | PGR | P06401 | 6/20 | 0.77 |
| ▸ | LMNA | P02545 | 5/20 | 0.77 |
| ▸ | AR | P10275 | 5/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.77 |
| ▸ | MAPT | P10636 | 2/20 | 0.77 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 2/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.70 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.70 |
| ▸ | RAB9A | P51151 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Triamcinolone Acetonide SCHEMBL28103100 | 0.94 | CYP3A4 (0.87) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluocinonide SCHEMBL28122375 | 0.94 | HIF1A (0.75) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluocinonide SCHEMBL3475945 | 0.94 | HIF1A (0.75) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Flunisolide SCHEMBL20915050 | 0.90 | CYP3A4 (0.69) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Halcinonide SCHEMBL9810174 | 0.89 | CYP3A4 (0.68) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Triamcinolone Acetonide SCHEMBL1446089 | 0.88 | HIF1A (0.89) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Triamcinolone Acetonide SCHEMBL1561091 | 0.88 | HIF1A (0.89) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Flumethasone SCHEMBL5080186 | 0.88 | HIF1A (0.82) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluocinolone Acetonide SCHEMBL15256220 | 0.88 | NR3C1 (1.00) | HIF1ACYP3A4PGRNR3C1LMNA | |
| Fluocinolone Acetonide SCHEMBL13046617 | 0.88 | NR3C1 (1.00) | HIF1ACYP3A4PGRNR3C1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740187-A1 | MACULAR EDEMA PATIENT SELECTION METHOD AND TREATMENT WITH EYE IMPLANT COMPRISING A STEROID | Bausch & Lomb Incorporated (US) | 2007-01-10 | — | — | EP | claimed |
| WO-2005099717-A1 | MACULAR EDEMA PATIENT SELECTION METHOD AND TREATMENT WITH EYE IMPLANT COMPRISING A STEROID | BAUSCH & LOMB INCORPORATED (US) | 2005-10-27 | — | — | WO | claimed |
| US-20050226814-A1 | Diagnostic method and kit for implantation of a sustained release drug-delivery implant with a steroid | BAUSCH & LOMB INCORPORATED | 2005-10-13 | — | — | US | claimed |
| EP-1740187-A1 | MACULAR EDEMA PATIENT SELECTION METHOD AND TREATMENT WITH EYE IMPLANT COMPRISING A STEROID | Bausch & Lomb Incorporated (US) | 2007-01-10 | — | — | EP | disclosed |
| EP-1641435-A2 | RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2006-04-05 | — | — | EP | disclosed |
| WO-2005099717-A1 | MACULAR EDEMA PATIENT SELECTION METHOD AND TREATMENT WITH EYE IMPLANT COMPRISING A STEROID | BAUSCH & LOMB INCORPORATED (US) | 2005-10-27 | — | — | WO | disclosed |
| US-20050226814-A1 | Diagnostic method and kit for implantation of a sustained release drug-delivery implant with a steroid | BAUSCH & LOMB INCORPORATED | 2005-10-13 | — | — | US | disclosed |
| US-20050031669-A1 | Rate controlled release of a pharmaceutical agent in a biodegradable device | BAUSCH & LOMB INCORPORATED (US) | 2005-02-10 | — | — | US | disclosed |
| WO-2004112748-A2 | RATE CONTROLLED RELEASE OF A PHARMACEUTICAL AGENT IN A BIODEGRADABLE DEVICE | BAUSCH & LOMB INCORPORATED (US) | 2004-12-29 | — | — | WO | disclosed |
| US-20040253293-A1 | Rate controlled release of a pharmaceutical agent in a biodegradable device | BAUSCH & LOMB INCORPORATED | 2004-12-16 | — | — | US | disclosed |
| EP-1399161-A2 | SUSTAINED-RELEASE ANALGESIC COMPOUNDS | Control Delivery Systems (US) | 2004-03-24 | — | — | EP | disclosed |
| WO-2002098427-A2 | SUSTAINED-RELEASE ANALGESIC COMPOUNDS | CONTROL DELIVERY SYSTEMS (US) | 2002-12-12 | — | — | WO | disclosed |