Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809617 | 0.85 | ALDH1A1 (0.39) | SCN9ALMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22809449 | 0.81 | SCN9A (0.50) | SCN9ALMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9886104 | 0.79 | LMNA (0.43) | LMNAALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL22809637 | 0.77 | ALDH1A1 (0.51) | SCN9ALMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22809533 | 0.75 | SCN9A (0.42) | SCN9ALMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22809587 | 0.71 | SCN9A (0.42) | SCN9ALMNAALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22809636 | 0.70 | PPARG (0.37) | LMNAALDH1A1SMN1; SMN2HPGDNPSR1 | |
| SCHEMBL13865701 | 0.70 | AGBL2 (0.47) | ALDH1A1SMN1; SMN2HPGDNPSR1L3MBTL1 | |
| SCHEMBL19055601 | 0.69 | AGBL2 (0.44) | LMNAALDH1A1HPGDNPSR1L3MBTL1 | |
| SCHEMBL24675316 | 0.68 | AGBL2 (0.46) | ALDH1A1SMN1; SMN2HPGDNPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3487839-B1 | AMIDE DERIVATIVES AS NAV1.7 AND NAV1.8 BLOCKERS | RAQUALIA PHARMA INC (JP) | 2020-12-23 | — | — | EP | disclosed |