Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 3/20 | 0.47 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.43 |
| ▸ | ERN1 | O75460 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809701 | 0.86 | SCN8A (0.48) | SCN8ASCN10ATDP1HTR1ASLC6A2 | |
| SCHEMBL3325788 | 0.85 | ERN1 (0.41) | SCN8ASCN10ATDP1ERN1ALDH1A1 | |
| SCHEMBL4509584 | 0.81 | TDP1 (0.44) | TDP1SLC6A2ERN1SLC6A4ALDH1A1 | |
| SCHEMBL23709745 | 0.77 | TDP1 (0.52) | TDP1SLC6A2ERN1SLC6A4ALDH1A1 | |
| SCHEMBL5989471 | 0.75 | LMNA (0.42) | TDP1HTR1ASLC6A2ERN1SLC6A4 | |
| SCHEMBL20535365 | 0.75 | TDP1 (0.57) | TDP1SLC6A2ERN1ALDH1A1 | |
| SCHEMBL23709944 | 0.74 | SLC6A4 (0.50) | TDP1HTR1ASLC6A2ERN1SLC6A4 | |
| SCHEMBL5991434 | 0.74 | SCN8A (0.45) | SCN8ASCN10ATDP1SLC6A2ERN1 | |
| SCHEMBL18570512 | 0.74 | TTR (0.48) | SCN8ASCN10ATDP1SLC6A2SLC6A4 | |
| SCHEMBL5991889 | 0.73 | LMNA (0.46) | SCN8ASCN10ATDP1ERN1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |