Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809757 | 0.89 | ALDH1A1 (0.44) | SCN8ASCN10ATDP1ALDH1A1HTT | |
| SCHEMBL18570512 | 0.88 | TTR (0.48) | SCN8ASCN10ATDP1SLC6A2SLC6A4 | |
| SCHEMBL4509584 | 0.86 | TDP1 (0.44) | TDP1ALDH1A1HTTSLC6A2SLC6A4 | |
| SCHEMBL5992341 | 0.85 | SCN8A (0.47) | SCN8ASCN10ATDP1ALDH1A1SLC6A2 | |
| SCHEMBL18570618 | 0.84 | SCN8A (0.47) | SCN8ASCN10ATDP1ALDH1A1SLC6A2 | |
| SCHEMBL21129891 | 0.83 | HSPB1 (0.41) | SCN8ASCN10AALDH1A1HTTHSPB1 | |
| SCHEMBL19524123 | 0.82 | ERN1 (0.41) | ALDH1A1HTTHSPB1TRPA1EPAS1 | |
| SCHEMBL5991889 | 0.81 | LMNA (0.46) | SCN8ASCN10ATDP1ALDH1A1SLC6A4 | |
| SCHEMBL275968 | 0.80 | HSPB1 (0.46) | ALDH1A1HTTHSPB1TRPA1EPAS1 | |
| SCHEMBL5988752 | 0.79 | SCN8A (0.47) | SCN8ASCN10AALDH1A1HTTHSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |
| EP-2953931-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2017-03-01 | — | — | EP | disclosed |
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |