Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.48 |
| ▸ | SCN10A | Q9Y5Y9 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | ERN1 | O75460 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22809650 | 0.86 | SCN8A (0.47) | SCN8ASCN10AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL3325788 | 0.85 | ERN1 (0.41) | SCN8ASCN10AERN1TDP1ALDH1A1 | |
| SCHEMBL4509584 | 0.79 | TDP1 (0.44) | SLC6A2SLC6A4ERN1TDP1NPSR1 | |
| SCHEMBL4515945 | 0.79 | NPSR1 (0.46) | SLC6A2SLC6A4ERN1TDP1NPSR1 | |
| SCHEMBL5992341 | 0.75 | SCN8A (0.47) | SCN8ASCN10ASLC6A2SLC6A4TDP1 | |
| SCHEMBL5989756 | 0.73 | L3MBTL1 (0.58) | SLC6A4TDP1NPSR1ALDH1A1HTR2A | |
| SCHEMBL5989471 | 0.73 | LMNA (0.42) | HTR1ASLC6A2SLC6A4ERN1TDP1 | |
| SCHEMBL19524141 | 0.73 | SCN8A (0.51) | SCN8ASCN10AHTR1ASLC6A2SLC6A4 | |
| SCHEMBL23709944 | 0.72 | SLC6A4 (0.50) | HTR1ASLC6A2SLC6A4ERN1TDP1 | |
| SCHEMBL5991434 | 0.71 | SCN8A (0.45) | SCN8ASCN10ASLC6A2SLC6A4ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |