Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 5/20 | 0.38 |
| ▸ | NOS2 | P35228 | 5/20 | 0.38 |
| ▸ | NOS1 | P29475 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.32 |
| ▸ | USP7 | Q93009 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | AHCY | P23526 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31568933 | 0.81 | NOS3 (0.38) | NOS3NOS2NOS1DAOVRK1 | |
| SCHEMBL7361562 | 0.80 | NOS3 (0.36) | NOS3NOS2NOS1VRK1AHCY | |
| SCHEMBL31489254 | 0.77 | LMNA (0.37) | NOS3NOS2NOS1DAOVRK1 | |
| SCHEMBL2222027 | 0.76 | NOS3 (0.38) | NOS3NOS2NOS1DAOVRK1 | |
| SCHEMBL5809638 | 0.75 | NOS3 (0.46) | NOS3NOS2NOS1USP7 | |
| SCHEMBL20822293 | 0.75 | NOS3 (0.46) | NOS3NOS2NOS1USP7 | |
| Ammonia Solution, Strong SCHEMBL29016866 | 0.73 | NOS3 (0.44) | NOS3NOS2NOS1USP7 | |
| SCHEMBL14853133 | 0.73 | LMNA (0.41) | NOS3NOS2NOS1DAOVRK1 | |
| SCHEMBL18952054 | 0.73 | NOS3 (0.35) | NOS3NOS2NOS1DAOVRK1 | |
| SCHEMBL30867865 | 0.73 | LMNA (0.41) | NOS3NOS2NOS1DAOVRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3239134-B1 | PYRIDONE AMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMA (US) | 2020-12-23 | — | — | EP | disclosed |