Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13833817 | 0.74 | BTK (0.39) | BTK | |
| SCHEMBL14723341 | 0.72 | BTK (0.35) | BTK | |
| SCHEMBL16935059 | 0.68 | MLYCD (0.42) | — | |
| SCHEMBL20715407 | 0.66 | KDM4E (0.45) | — | |
| SCHEMBL22854174 | 0.66 | UHRF1 (0.39) | — | |
| SCHEMBL22296706 | 0.66 | BTK (0.34) | BTK | |
| SCHEMBL18951811 | 0.65 | TUBB4A (0.51) | — | |
| SCHEMBL6474120 | 0.64 | — | — | |
| SCHEMBL30786149 | 0.62 | CHRNB2 (0.44) | BTK | |
| SCHEMBL846377 | 0.62 | MAPK1 (0.59) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3097101-B1 | ISOQUINOLINE DERIVATIVES AS MGAT2 INHIBITORS | MERCK SHARP & DOHME (US) | 2020-12-23 | — | — | EP | disclosed |