Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | RGS4 | P49798 | 1/20 | 0.35 |
| ▸ | RGS8 | P57771 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13033718 | 0.71 | MGLL (0.59) | KMT2ATP53LMNARGS4MAPT | |
| SCHEMBL18570477 | 0.68 | TP53 (0.38) | KMT2ACYP19A1CYP11B1CYP11B2TP53 | |
| SCHEMBL4800190 | 0.64 | MGLL (0.78) | KMT2ATP53LMNARGS4MAPT | |
| SCHEMBL24165285 | 0.61 | TP53 (0.38) | KMT2ACYP19A1CYP11B1CYP11B2TP53 | |
| SCHEMBL12704514 | 0.60 | TP53 (0.53) | KMT2ATP53LMNARGS4MAPT | |
| SCHEMBL14286721 | 0.59 | MGLL (0.75) | TP53LMNAMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL19002513 | 0.59 | ALDH1A1 (0.66) | KMT2ATP53LMNAMAPTGAA | |
| SCHEMBL28635748 | 0.59 | MAPT (0.52) | KMT2ATP53LMNARGS4MAPT | |
| SCHEMBL29820192 | 0.57 | CASP3 (0.65) | MAPT | |
| SCHEMBL8737445 | 0.57 | CASP3 (0.65) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3556752-B1 | N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LTD (GB) | 2022-01-05 | — | — | EP | disclosed |
| EP-3567037-B1 | N-((HET)ARYLMETHYL)-HETEROARYL-CARBOXAMIDES COMPOUNDS AS PLASMA KALLIKREIN INHIBITORS | KALVISTA PHARMACEUTICALS LTD (GB) | 2020-12-23 | — | — | EP | disclosed |