Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.83 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.77 |
| ▸ | DRD2 | P14416 | 3/20 | 0.62 |
| ▸ | DRD4 | P21917 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.61 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10352286 | 0.97 | HRH3 (0.78) | HRH3SIGMAR1DRD2DRD4SLC6A4 | |
| SCHEMBL10669091 | 0.91 | HRH3 (1.00) | HRH3SIGMAR1SLC6A4LTA4HHTR1A | |
| SCHEMBL5708997 | 0.90 | HRH3 (0.72) | HRH3SIGMAR1DRD2DRD4LTA4H | |
| SCHEMBL17294993 | 0.89 | HRH3 (0.97) | HRH3SIGMAR1SLC6A4LTA4HHTR1A | |
| SCHEMBL5709087 | 0.89 | HRH3 (0.71) | HRH3SIGMAR1DRD2DRD4SLC6A4 | |
| SCHEMBL18672550 | 0.87 | SIGMAR1 (1.00) | HRH3SIGMAR1SLC6A4HTR1A | |
| SCHEMBL11786563 | 0.87 | SIGMAR1 (0.71) | HRH3SIGMAR1DRD2DRD4HTR2B | |
| Hydrochloric Acid SCHEMBL27726278 | 0.86 | SIGMAR1 (0.97) | HRH3SIGMAR1SLC6A4HTR1A | |
| SCHEMBL18917601 | 0.84 | SLC6A3 (0.77) | HRH3SIGMAR1DRD2SLC6A4SLC6A3 | |
| SCHEMBL15962434 | 0.83 | SIGMAR1 (0.82) | SIGMAR1DRD2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3253734-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV MICHIGAN REGENTS (US) | 2020-12-23 | — | — | EP | disclosed |