Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 10/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PDE8B | O95263 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1412426 | 0.91 | AKR1C3 (0.51) | AKR1C3ALOX15L3MBTL1PDE8BAKR1C2 | |
| SCHEMBL1412402 | 0.84 | ALOX15 (0.52) | AKR1C3ALOX15L3MBTL1PDE8BAKR1C2 | |
| SCHEMBL1412502 | 0.83 | AKR1C3 (0.45) | AKR1C3ALOX15L3MBTL1PDE8BAKR1C2 | |
| SCHEMBL24569500 | 0.83 | AKR1C3 (0.51) | AKR1C3ALOX15L3MBTL1PDE8BAKR1C2 | |
| SCHEMBL1412433 | 0.80 | UCHL1 (0.54) | AKR1C3ALOX15L3MBTL1PDE8BKMT2A | |
| SCHEMBL3731878 | 0.80 | UCHL1 (0.54) | AKR1C3ALOX15L3MBTL1PDE8BKMT2A | |
| SCHEMBL23484362 | 0.80 | ALOX15 (0.56) | AKR1C3ALOX15L3MBTL1PDE8BMEN1 | |
| SCHEMBL1412545 | 0.79 | PDE8B (0.50) | AKR1C3ALOX15L3MBTL1PDE8BAKR1C2 | |
| SCHEMBL22816868 | 0.78 | AKR1C3 (0.42) | AKR1C3ALOX15L3MBTL1PDE8BAKR1C2 | |
| SCHEMBL22815606 | 0.76 | ALOX15 (0.58) | AKR1C3ALOX15L3MBTL1PDE8BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11384055-B2 | Glycolate oxidase inhibitors for the treatment of disease | BIOMARIN PHARMACEUTICAL INC. (US) | 2022-07-12 | — | — | US | disclosed |
| US-20210171474-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2021-06-10 | — | — | US | disclosed |
| WO-2020257487-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2020-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11384055-B2 | Glycolate oxidase inhibitors for the treatment of disease | XDH, PNPO, AGXT | AKR1C3 345/4885ALOX15 176/4885L3MBTL1 1830/4885 |
| US-20210171474-A1 | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE | XDH, PNPO, AGXT | AKR1C3 345/4885ALOX15 176/4885L3MBTL1 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.