Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PREP | P48147 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27117596 | 0.88 | USP2 (0.36) | NPC1UCHL1USP2SMN1; SMN2HSD17B10 | |
| SCHEMBL34469218 | 0.81 | NPC1 (0.36) | NPC1UCHL1LMNANPSR1 | |
| SCHEMBL2395205 | 0.79 | USP2 (0.39) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL24918232 | 0.79 | USP2 (0.39) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL16224559 | 0.79 | USP2 (0.39) | USP2SMN1; SMN2HSD17B10NR1H2CHRM2 | |
| SCHEMBL22820950 | 0.78 | NPC1 (0.38) | NPC1UCHL1USP2SMN1; SMN2HSD17B10 | |
| SCHEMBL22820871 | 0.75 | USP2 (0.36) | NPC1UCHL1USP2SMN1; SMN2HSD17B10 | |
| SCHEMBL31708282 | 0.75 | ALDH1A1 (0.36) | NPC1UCHL1USP2SMN1; SMN2HSD17B10 | |
| SCHEMBL4766170 | 0.73 | HSD17B10 (0.42) | NPC1UCHL1HSD17B10LMNANPSR1 | |
| SCHEMBL3805159 | 0.73 | HSD17B10 (0.42) | NPC1UCHL1HSD17B10LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032568-A2 | POLYCYCLIC HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF THE METABOTROPIC GLUTAMATE 5 RECEPTOR | AstraZeneca AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007130823-A2 | POLYCYCLIC HETEROCYCLIC COMPOUNDS AND THEIR USE AS MODULATORS OF THE METABOTROPIC GLUTAMATE 5 RECEPTOR | ASTRAZENECA AB (SE) | 2007-11-15 | — | — | WO | disclosed |