Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 13/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.45 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20758346 | 1.00 | PAX8 (0.53) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL16712702 | 1.00 | PAX8 (0.53) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL18125117 | 1.00 | PAX8 (0.53) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL24449479 | 0.75 | PAX8 (0.48) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL24022488 | 0.75 | PAX8 (0.48) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL25988749 | 0.74 | KCNH2 (0.47) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL24450182 | 0.74 | KCNH2 (0.51) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL24450176 | 0.73 | KCNH2 (0.52) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL22822021 | 0.72 | PAX8 (0.41) | PAX8KCNH2MEN1NPC1POLB | |
| SCHEMBL24450180 | 0.72 | KCNH2 (0.51) | PAX8KCNH2MEN1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11325913-B2 | Compounds and methods for the treatment of malaria | THE BROAD INSTITUTE, INC. (US) | 2022-05-10 | — | — | US | disclosed |
| US-20200399276-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA | THE BROAD INSTITUTE, INC. (US) | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11325913-B2 | Compounds and methods for the treatment of malaria | G6PD, CYP11B2, GLS2 | PAX8 4740/4885KCNH2 2910/4885MEN1 1899/4885 |
| US-20200399276-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA | G6PD, CYP11B2, GLS2 | PAX8 4740/4885KCNH2 2910/4885MEN1 1899/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.