Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | CCKBR | P32239 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.44 |
| ▸ | PADI6 | Q6TGC4 | 1/20 | 0.44 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.44 |
| ▸ | MME | P08473 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20777169 | 0.93 | CTSL (0.49) | NPC1RAB9ACNR1CNR2CTSL | |
| SCHEMBL22822775 | 0.92 | CNR1 (0.51) | NPC1RAB9ACNR1CNR2CCKBR | |
| SCHEMBL22822798 | 0.90 | NPC1 (0.60) | NPC1RAB9ACNR1CNR2CCKBR | |
| SCHEMBL24119851 | 0.87 | MCHR1 (0.50) | CNR1CNR2MCHR1ALDH1A1MAPT | |
| SCHEMBL20777199 | 0.85 | CTSL (0.52) | CNR1CNR2MAPTCTSL | |
| SCHEMBL20777202 | 0.85 | CTSL (0.52) | CNR1CNR2MAPTCTSL | |
| SCHEMBL20777178 | 0.85 | CTSL (0.52) | CNR1CNR2MAPTCTSL | |
| SCHEMBL20777212 | 0.83 | NPC1 (0.55) | NPC1RAB9AMAPTCTSL | |
| SCHEMBL24120019 | 0.83 | CNR1 (0.51) | NPC1RAB9ACNR1CNR2CCKBR | |
| SCHEMBL22822802 | 0.83 | NPC1 (0.55) | NPC1RAB9AMAPTCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210395203-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. | 2021-12-23 | — | — | US | disclosed |
| US-20200399219-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | PLEX PHARMACEUTICALS, INC. | 2020-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399219-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | FKBP2, FKBP1B, FKBP1A | NPC1 1443/4885RAB9A 1223/4885CNR1 3234/4885 |
| US-20210395203-A1 | DUAL ACTING FKBP12 AND FKBP52 INHIBITORS | FKBP2, FKBP1B, FKBP1A | NPC1 1443/4885RAB9A 1223/4885CNR1 3234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.