SCHEMBL22825596

SCHEMBL22825596

COc1ccc(N2c3ccccc3C3(c4ccccc4-c4ccccc43)c3cc(C=C4C(=O)c5cc6ccccc6cc5C4=O)ccc32)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 8/20 0.46
KMT2A Q03164 7/20 0.46
ALDH1A1 P00352 7/20 0.46
MEN1 O00255 5/20 0.46
KDM4E B2RXH2 3/20 0.46
USP2 O75604 1/20 0.42
PKM P14618 1/20 0.42
PGR P06401 1/20 0.40
KDM1A O60341 2/20 0.40
LCK P06239 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
ALPL P05186 1/20 0.39
ALPI P09923 1/20 0.39
ALPG P10696 1/20 0.39
HPGD P15428 2/20 0.37
NR1H2 P55055 1/20 0.37
NR1H3 Q13133 1/20 0.37
CRHBP P24387 1/20 0.36
CRHR2 Q13324 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22825606 0.90 MAPT (0.39) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL22825597 0.88 MEN1 (0.38) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL17778892 0.88 KMT2A (0.45) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL22826499 0.88 NR1H2 (0.39) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL22826057 0.87 MAPT (0.39) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL17779147 0.84 KMT2A (0.45) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL25849786 0.84 LCK (0.39) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL25850851 0.84 LCK (0.39) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL22825590 0.82 LCK (0.34) MAPTKMT2AALDH1A1MEN1KDM4E
SCHEMBL22826498 0.82 POLB (0.40) MAPTKMT2AALDH1A1MEN1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200403163-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND FUJIFILM CORPORATION (JP) 2020-12-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200403163-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND CRY1, CRY2, PIEZO1 MAPT 1175/4885KMT2A 1798/4885ALDH1A1 1183/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.