SCHEMBL22826014

SCHEMBL22826014

Cc1cc(C)c(-c2ccc3c(c2)C2(c4ccccc4-c4ccccc42)c2cc(C=C4C(=O)c5cc6ccccc6cc5C4=O)ccc2N3c2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.39

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LCK P06239 2/20 0.32
MAPT P10636 3/20 0.31
KMT2A Q03164 3/20 0.31
USP2 O75604 1/20 0.31
PKM P14618 1/20 0.31
DHODH Q02127 1/20 0.31
ALDH1A1 P00352 2/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
MEN1 O00255 1/20 0.31
ALPL P05186 1/20 0.31
ALPI P09923 1/20 0.31
ALPG P10696 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
BCL2 P10415 1/20 0.30
BAX Q07812 1/20 0.30
BCL2L1 Q07817 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22826013 0.93 BCL2 (0.34) LCKMAPTKMT2AUSP2PKM
SCHEMBL22826012 0.93 DHODH (0.35) LCKMAPTKMT2AUSP2PKM
SCHEMBL22825590 0.92 LCK (0.34) LCKMAPTKMT2AUSP2PKM
SCHEMBL26746791 0.91 BCL2 (0.32) LCKMAPTKMT2AUSP2PKM
SCHEMBL22826008 0.91 DHODH (0.35) LCKMAPTKMT2AUSP2PKM
SCHEMBL22826009 0.88 PDK2 (0.35) MAPTKMT2AALDH1A1MEN1BCL2
SCHEMBL22826011 0.84 MAPT (0.33) LCKMAPTKMT2AUSP2PKM
SCHEMBL22826060 0.82 KMT2A (0.37) LCKMAPTKMT2AUSP2PKM
SCHEMBL25849749 0.82 BCL2 (0.32) LCKMAPTKMT2AUSP2PKM
SCHEMBL25850676 0.81 BCL2 (0.32) LCKMAPTKMT2AUSP2PKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20200403163-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND FUJIFILM CORPORATION (JP) 2020-12-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200403163-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND CRY1, CRY2, PIEZO1 LCK 4051/4885MAPT 1175/4885KMT2A 1798/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.