Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.31 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.31 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23329003 | 0.83 | GBA1 (0.42) | GBA1PHLPP2PDK2AAK1HTR2C | |
| SCHEMBL21999069 | 0.78 | MMP2 (0.37) | GBA1PHLPP2PDK2AAK1 | |
| SCHEMBL3938663 | 0.78 | PHLPP2 (0.43) | GBA1PHLPP2PDK2AAK1ALDH1A1 | |
| SCHEMBL15807564 | 0.77 | LMNA (0.41) | PHLPP2PDK2 | |
| SCHEMBL4873059 | 0.76 | ESRRG (0.42) | GBA1PHLPP2PDK2AAK1ACHE | |
| SCHEMBL25570107 | 0.76 | PRSS1 (0.43) | GBA1PHLPP2PDK2AAK1CYP2D6 | |
| SCHEMBL19998347 | 0.75 | MT-CO2 (0.46) | PHLPP2MT-CO2ALDH1A1TP53CYP3A4 | |
| SCHEMBL19998349 | 0.75 | MT-CO2 (0.46) | PHLPP2MT-CO2ALDH1A1TP53CYP3A4 | |
| SCHEMBL18011040 | 0.74 | CYP3A4 (0.41) | PHLPP2AAK1MT-CO2ALDH1A1TP53 | |
| SCHEMBL991922 | 0.74 | PDK2 (0.53) | PHLPP2PDK2ALDH1A1TDP1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020256751-A1 | ANTIB0DY-ALK5 INHIBITOR CONJUGATES AND THEIR USES | SYNTHIS, LLC (US) | 2020-12-24 | — | — | WO | disclosed |