Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 12/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PAK4 | O96013 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.47 |
| ▸ | IGF1R | P08069 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | LTK | P29376 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22827972 | 0.81 | PTGS2 (0.70) | PTGS2TP53TSHRCLK4CYP1A2 | |
| SCHEMBL22828096 | 0.81 | PTGS2 (1.00) | PTGS2 | |
| SCHEMBL12321866 | 0.79 | MEN1 (0.53) | PTGS2AURKADAPK3JAK2PAK4 | |
| SCHEMBL22827975 | 0.79 | TP53 (0.48) | PTGS2NPC1TP53TSHRRAB9A | |
| SCHEMBL3450960 | 0.78 | ABCG2 (0.54) | NPC1TP53RAB9AMEN1KMT2A | |
| SCHEMBL22828098 | 0.78 | PTGS2 (0.53) | PTGS2NPC1TP53TSHRRAB9A | |
| SCHEMBL10754815 | 0.76 | PTGS2 (0.57) | PTGS2MEN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL10395225 | 0.74 | LMNA (0.56) | PTGS2MEN1CYP1A2CYP2C9KMT2A | |
| SCHEMBL1319082 | 0.74 | SMN1; SMN2 (0.68) | PTGS2AURKADAPK3JAK2PAK4 | |
| SCHEMBL9884921 | 0.73 | DAPK3 (0.56) | PTGS2AURKADAPK3JAK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257653-A1 | RADIOLABELED COMPOUNDS AND USES THEREOF | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-12-24 | — | — | WO | disclosed |