Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P4HB | P07237 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.35 |
| ▸ | LPL | P06858 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | F11 | P03951 | 2/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283055 | 1.00 | P4HB (0.46) | P4HBCHRM3LIPGLPLF2 | |
| SCHEMBL2283060 | 1.00 | P4HB (0.46) | P4HBCHRM3LIPGLPLF2 | |
| SCHEMBL2281172 | 0.84 | P4HB (0.44) | P4HBCHRM3LIPGLPLF2 | |
| SCHEMBL2281184 | 0.84 | P4HB (0.44) | P4HBCHRM3LIPGLPLF2 | |
| SCHEMBL2283388 | 0.82 | P4HB (0.42) | P4HBLIPGLPLF2F11 | |
| SCHEMBL2283382 | 0.82 | P4HB (0.42) | P4HBLIPGLPLF2F11 | |
| SCHEMBL2283537 | 0.76 | LIPG (0.43) | CHRM3LIPGLPLF2F11 | |
| SCHEMBL2283534 | 0.76 | LIPG (0.43) | CHRM3LIPGLPLF2F11 | |
| SCHEMBL3273490 | 0.73 | P4HB (0.44) | P4HBLIPGLPLF2F11 | |
| SCHEMBL3273502 | 0.73 | P4HB (0.44) | P4HBLIPGLPLF2F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2078007-B1 | IKK-BETA SERINE-THREONINE PROTEIN KINASE INHIBITORS | CHROMA THERAPEUTICS LTD (GB) | 2011-08-31 | — | — | EP | disclosed |
| US-8003695-B2 | IKK-beta serine-threonine protein kinase inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-08-23 | — | — | US | disclosed |