Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.43 |
| ▸ | LPL | P06858 | 1/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.34 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2283534 | 1.00 | LIPG (0.43) | LIPGLPLKEAP1NFE2L2CYP3A4 | |
| SCHEMBL1200148 | 0.76 | LIPG (0.44) | LIPGLPLHIF1ATAAR1GLA | |
| SCHEMBL2283060 | 0.76 | P4HB (0.46) | LIPGLPLKEAP1NFE2L2F2 | |
| SCHEMBL2283055 | 0.76 | P4HB (0.46) | LIPGLPLKEAP1NFE2L2F2 | |
| SCHEMBL2283073 | 0.76 | P4HB (0.46) | LIPGLPLKEAP1NFE2L2F2 | |
| SCHEMBL2145222 | 0.73 | LIPG (0.58) | LIPGLPLCA1CA2CA9 | |
| SCHEMBL2283542 | 0.72 | LIPG (0.41) | LIPGLPLCYP3A4CYP2D6HIF1A | |
| SCHEMBL12374507 | 0.72 | MAPK14 (0.45) | LIPGLPL | |
| SCHEMBL18706929 | 0.71 | LIPG (0.58) | LIPGLPLHIF1A | |
| SCHEMBL25811088 | 0.71 | LIPG (0.58) | LIPGLPLTAAR1ROCK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003695-B2 | IKK-beta serine-threonine protein kinase inhibitors | CHROMA THERAPEUTICS LTD. (GB) | 2011-08-23 | — | — | US | disclosed |