Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SLC16A3 | O15427 | 5/20 | 0.59 |
| ▸ | SLC16A1 | P53985 | 3/20 | 0.41 |
| ▸ | MCTS1 | Q9ULC4 | 3/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL1604097 | 1.00 | SLC16A3 (0.59) | SLC16A3SLC16A1MCTS1PDE5ASSTR4 | |
| Maleic Acid SCHEMBL1604096 | 1.00 | SLC16A3 (0.59) | SLC16A3SLC16A1MCTS1PDE5ASSTR4 | |
| SCHEMBL1603534 | 0.93 | SLC16A3 (0.59) | SLC16A3SLC16A1MCTS1PDE5ASSTR4 | |
| SCHEMBL1603997 | 0.81 | SLC16A3 (0.70) | SLC16A3SLC16A1MCTS1PDE5ASSTR4 | |
| SCHEMBL1603998 | 0.77 | SLC16A3 (0.59) | SLC16A3SLC16A1MCTS1PDE5ASSTR4 | |
| SCHEMBL29562615 | 0.76 | SLC16A3 (0.72) | SLC16A3PDE5ASSTR4CNR1ACHE | |
| SCHEMBL17510201 | 0.76 | SLC16A3 (0.72) | SLC16A3PDE5ASSTR4CNR1ACHE | |
| SCHEMBL927377 | 0.76 | SLC16A3 (0.72) | SLC16A3PDE5ASSTR4CNR1ACHE | |
| Bindarit SCHEMBL187885 | 0.75 | SLC16A3 (1.00) | SLC16A3SLC16A1MCTS1SSTR4CNR1 | |
| Bindarit SCHEMBL29387325 | 0.75 | SLC16A3 (1.00) | SLC16A3SLC16A1MCTS1SSTR4CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990433-A1 | PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES | Translatum Medicus Inc. (CA) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020261158-A1 | PROCESSES OF MAKING 2-((1-BENZYL-1H-INDAZOL-3-YL)METHOXY)-2-METHYLPROPANOIC ACID AND ITS DERIVATIVES | Translatum Medicus Inc. (CA) | 2020-12-30 | — | — | WO | disclosed |