Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 7/20 | 0.69 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.69 |
| ▸ | TAS2R14 | Q9NYV8 | 6/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29380515 | 1.00 | DHODH (0.69) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| SCHEMBL26643080 | 0.88 | DHODH (0.69) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| SCHEMBL31022555 | 0.88 | DHODH (0.69) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| SCHEMBL22853088 | 0.87 | DHODH (0.62) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| SCHEMBL30294252 | 0.87 | DHODH (0.62) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| SCHEMBL22853093 | 0.82 | DHODH (0.47) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| SCHEMBL30294777 | 0.82 | DHODH (0.47) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| Flunixin SCHEMBL29439899 | 0.82 | DHODH (1.00) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| Flunixin SCHEMBL31696761 | 0.82 | DHODH (1.00) | DHODHHDAC6TAS2R14CYP1A2HIF1A | |
| Flunixin SCHEMBL42911 | 0.82 | DHODH (1.00) | DHODHHDAC6TAS2R14CYP1A2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3990436-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2022-05-04 | — | — | EP | disclosed |
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |