Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.55 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | TTR | P02766 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.53 |
| ▸ | MT-CO2 | P00403 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294252 | 1.00 | DHODH (0.62) | DHODHSMN1; SMN2ALDH1A1HTTAGTR1 | |
| SCHEMBL29380515 | 0.87 | DHODH (0.69) | DHODHSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL22833403 | 0.87 | DHODH (0.69) | DHODHSMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL22853093 | 0.81 | DHODH (0.47) | DHODHALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL30294777 | 0.81 | DHODH (0.47) | DHODHALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL22853164 | 0.81 | ALDH1A1 (0.52) | DHODHSMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL30294847 | 0.81 | ALDH1A1 (0.52) | DHODHSMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL22853174 | 0.80 | SORT1 (0.54) | DHODHALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL30294412 | 0.80 | SORT1 (0.54) | DHODHALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL22853060 | 0.79 | TOP1 (0.47) | DHODHSMN1; SMN2ALDH1A1HTTAGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |