Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 10/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294777 | 1.00 | DHODH (0.47) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL30294412 | 0.84 | SORT1 (0.54) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL22853174 | 0.84 | SORT1 (0.54) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL22833733 | 0.83 | MKNK2 (0.47) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL29382196 | 0.83 | MKNK2 (0.47) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL22833403 | 0.82 | DHODH (0.69) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL29380515 | 0.82 | DHODH (0.69) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL22853164 | 0.82 | ALDH1A1 (0.52) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL30294847 | 0.82 | ALDH1A1 (0.52) | DHODHHDAC6SORT1TAS2R14MEN1 | |
| SCHEMBL22853088 | 0.81 | DHODH (0.62) | DHODHHDAC6SORT1TAS2R14MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |