Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.42 |
| ▸ | LGMN | Q99538 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19582690 | 0.87 | HRH3 (0.38) | MAPTPOLBGPR119LGMNKMT2A | |
| SCHEMBL19087943 | 0.87 | MAPT (0.44) | MAPTPOLBLGMNKMT2AMEN1 | |
| SCHEMBL19601721 | 0.85 | MAPT (0.57) | MAPTPOLBLGMNKMT2AMEN1 | |
| SCHEMBL17305174 | 0.85 | LMNA (0.44) | MAPTKMT2AMEN1ALDH1A1FFAR4 | |
| SCHEMBL16001294 | 0.82 | LGMN (0.58) | MAPTPOLBGPR119LGMNKMT2A | |
| SCHEMBL19582717 | 0.81 | GABRA5 (0.42) | MAPTLGMNKMT2AMEN1ALDH1A1 | |
| SCHEMBL19386350 | 0.81 | MAPT (0.48) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL19601670 | 0.80 | CYP46A1 (0.48) | MAPTKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL19386342 | 0.80 | PIM1 (0.53) | — | |
| SCHEMBL19608849 | 0.80 | ACACB (0.35) | MAPTGPR119LGMNKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3455226-B1 | SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME | LUNDBECK LA JOLLA RESEARCH CENTER INC (US) | 2020-12-30 | — | — | EP | disclosed |