Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1685458 | 0.93 | KEAP1 (0.61) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| SCHEMBL2244319 | 0.93 | SMN1; SMN2 (0.61) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| SCHEMBL9444 | 0.89 | — | — | |
| Hydrochloric Acid SCHEMBL1168021 | 0.86 | KEAP1 (0.70) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| SCHEMBL1307205 | 0.86 | KEAP1 (0.70) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| Hydrochloric Acid SCHEMBL8859956 | 0.86 | KEAP1 (0.70) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| SCHEMBL27350451 | 0.86 | KEAP1 (0.70) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| SCHEMBL10917755 | 0.86 | KEAP1 (0.70) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| Ammonia Solution, Strong SCHEMBL726007 | 0.86 | KEAP1 (0.70) | SMN1; SMN2KEAP1ALOX15GLAKDM4E | |
| SCHEMBL13019 | 0.83 | KDM4E (0.56) | SMN1; SMN2KEAP1GLAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3799870-A1 | IRE-1A INHIBITORS | Fosun Orinove Pharmatech, Inc. (CN) | 2021-04-07 | — | — | EP | disclosed |
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |