Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22842858 | 0.84 | KCNA3 (0.36) | MAPTKDM4EKCNA3GAATHRB | |
| SCHEMBL22842881 | 0.82 | KCNA3 (0.35) | EPAS1KDM4EALDH1A1BRAFKCNA3 | |
| SCHEMBL22842882 | 0.80 | ALDH1A1 (0.44) | EPAS1MAPTLMNAKDM4EALDH1A1 | |
| SCHEMBL22842890 | 0.77 | BRAF (0.60) | BRAF | |
| SCHEMBL24753392 | 0.77 | CYP1A2 (0.38) | LMNAALDH1A1BRAFGAAGFER | |
| SCHEMBL22842863 | 0.76 | SLC22A12 (0.38) | EPAS1MAPTLMNABRAFKCNA3 | |
| SCHEMBL22842880 | 0.76 | KCNA3 (0.36) | MAPTKDM4EKCNA3GAATHRB | |
| SCHEMBL22842864 | 0.73 | KCNA3 (0.34) | EPAS1MAPTLMNAALDH1A1BRAF | |
| SCHEMBL22842857 | 0.70 | RPS6KA1 (0.35) | MAPTKDM4EKMT2ATHRB | |
| SCHEMBL22842867 | 0.70 | EPAS1 (0.36) | EPAS1MAPTLMNAALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261156-A1 | QUINAZOLIN-4-ONE DERIVATIVES USEFUL FOR THE TREATMENT OF BRAF-ASSOCIATED DISEASES AND DISORDERS | ARRAY BIOPHARMA INC. (US) | 2020-12-30 | — | — | WO | disclosed |