Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | ESRRB | O95718 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724987 | 0.82 | HPGD (0.51) | HPGDNPC1RAB9AESRRGSMN1; SMN2 | |
| SCHEMBL10282412 | 0.80 | RAB9A (0.86) | HPGDNPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL9967839 | 0.80 | FLT1 (0.52) | NPC1RAB9AESRRBESRRGFLT1 | |
| SCHEMBL29077678 | 0.80 | HPGD (0.71) | HPGDNPC1RAB9AP2RX7SMN1; SMN2 | |
| SCHEMBL16544523 | 0.79 | KDM1A (0.50) | HPGDNPC1RAB9ASMN1; SMN2CRHR1 | |
| SCHEMBL24665390 | 0.79 | NTRK1 (0.52) | HPGDNPC1RAB9ANTRK1SLC6A12 | |
| SCHEMBL28378463 | 0.78 | HPGD (0.69) | HPGDNPC1RAB9AP2RX7ESRRB | |
| SCHEMBL9967851 | 0.77 | RAB9A (0.48) | HPGDNPC1RAB9AESRRGSMN1; SMN2 | |
| SCHEMBL4516890 | 0.77 | HPGD (0.68) | HPGDNPC1RAB9AP2RX7FLT1 | |
| SCHEMBL1820539 | 0.77 | HPGD (0.68) | HPGDNPC1RAB9AP2RX7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | HPGD 1777/4885NPC1 5/4885RAB9A 488/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | HPGD 1777/4885NPC1 5/4885RAB9A 488/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | HPGD 1777/4885NPC1 5/4885RAB9A 488/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.