Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | TNKS | O95271 | 1/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.46 |
| ▸ | LDLR | P01130 | 1/20 | 0.44 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10154082 | 0.90 | IDO1 (0.46) | IDO1HPGDSKIF11TNKSTNKS2 | |
| SCHEMBL19016861 | 0.84 | KIF11 (0.47) | IDO1HPGDSKIF11LDLRPCSK9 | |
| SCHEMBL13589293 | 0.81 | IDO1 (0.44) | IDO1HPGDSLDLRPCSK9GPR119 | |
| SCHEMBL17300880 | 0.80 | IDO1 (0.62) | IDO1HPGDSKIF11LDLRPCSK9 | |
| SCHEMBL1502339 | 0.79 | IDO1 (0.51) | IDO1HPGDSLDLRPCSK9GPR119 | |
| SCHEMBL20249405 | 0.77 | HPGDS (0.51) | IDO1HPGDSLDLRPCSK9GPR119 | |
| SCHEMBL24185698 | 0.77 | IDO1 (0.50) | IDO1HPGDSLDLRPCSK9GPR119 | |
| SCHEMBL10985317 | 0.77 | IDO1 (0.53) | IDO1HPGDSLDLRPCSK9GPR119 | |
| SCHEMBL5779888 | 0.77 | IDO1 (0.50) | IDO1HPGDSLDLRPCSK9GPR119 | |
| Ammonia Solution, Strong SCHEMBL28862527 | 0.77 | IDO1 (0.50) | IDO1HPGDSLDLRPCSK9GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2022-01-06 | — | — | US | disclosed |
| US-11136321-B2 | Tricyclic compounds | ALIGOS THERAPEUTICS, INC. (US) | 2021-10-05 | — | — | US | disclosed |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | ALIGOS THERAPEUTICS, INC. | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220000874-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | IDO1 2823/4885HPGDS 2425/4885KIF11 1584/4885 |
| US-11136321-B2 | Tricyclic compounds | SLC10A1, PKD1, CEL | IDO1 2823/4885HPGDS 2425/4885KIF11 1584/4885 |
| US-20200407361-A1 | TRICYCLIC COMPOUNDS | SLC10A1, PKD1, CEL | IDO1 2823/4885HPGDS 2425/4885KIF11 1584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.