Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 2/20 | 0.65 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.65 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.65 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.65 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.65 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.65 |
| ▸ | AXL | P30530 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | FLT4 | P35916 | 2/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.47 |
| ▸ | INSR | P06213 | 1/20 | 0.47 |
| ▸ | CDK1 | P06493 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3754835 | 0.79 | PRKAB2 (0.54) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL2813127 | 0.79 | PRKAB1 (1.00) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL2281774 | 0.76 | PRKAB2 (0.51) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL16112670 | 0.74 | PRKAB2 (0.50) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL17057354 | 0.73 | PRKAB2 (0.38) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL12517742 | 0.73 | PRKAB2 (0.49) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL12505413 | 0.73 | IRAK4 (0.43) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL2227680 | 0.72 | PLK4 (0.48) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL17080357 | 0.72 | PRKAB2 (0.47) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL13822288 | 0.72 | KDR (0.68) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12522595-B2 | Bicyclic ether O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors | BIOGEN MA INC. (US) | 2026-01-13 | — | — | US | disclosed |
| WO-2025068090-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES | GALAPAGOS NV (BE) | 2025-04-03 | — | — | WO | disclosed |
| US-20220106305-A1 | BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS | BIOGEN MA INC. | 2022-04-07 | — | — | US | disclosed |
| WO-2020163193-A1 | BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS | BIOGEN MA INC. (US) | 2020-08-13 | — | — | WO | disclosed |
| EP-2523552-B1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |
| EP-2523552-B1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-05-13 | — | — | EP | disclosed |
| US-8946237-B2 | Pyrazolo[1,5-A]pyrimidines as mark inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946237-B2 | Pyrazolo[1,5-A]pyrimidines as mark inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-02-03 | — | — | US | disclosed |
| US-8946237-B2 | Pyrazolo[1,5-A]pyrimidines as mark inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-02-03 | — | — | US | disclosed |
| US-20130210838-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME LLC | 2013-08-15 | — | — | US | disclosed |
| US-20130210838-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME LLC | 2013-08-15 | — | — | US | disclosed |
| US-20130210838-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME LLC | 2013-08-15 | — | — | US | disclosed |
| EP-2523552-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-11-21 | — | — | EP | disclosed |
| WO-2011087999-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-21 | — | — | WO | disclosed |
| WO-2011087999-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210838-A1 | PYRAZOLO[1,5-A]PYRIMIDINES AS MARK INHIBITORS | MARK3, MARK4, MARK1 | PRKAB2 321/4885PRKAG1 94/4885PRKAA2 459/4885 |
| US-20220106305-A1 | BICYCLIC ETHER O-GLYCOPROTEIN-2-ACETAMIDO-2-DEOXY-3-D-GLUCOPYRANOSIDASE INHIBITORS | ENGASE, UGGT1, MGAT3 | PRKAB2 3972/4885PRKAG1 3841/4885PRKAA2 4010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.