Sugi Predict

Sugi Predict / Compounds / Tyrosine

Tyrosine

Tyrosine

SCHEMBL2284684

C[C@H](N)C(=O)OC(=O)[C@@H](N)Cc1ccccc1.N[C@@H](Cc1ccc(O)cc1)C(=O)O

nearest known ligand 0.63

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC7A5 Q01650 6/20 0.63
▸ PTGS1 P23219 2/20 0.58
▸ ALPI P09923 1/20 0.58
▸ PKM P14618 1/20 0.58
▸ XIAP P98170 1/20 0.58
▸ GRIA2 P42262 1/20 0.46
▸ SLC1A3 P43003 1/20 0.44
▸ SLC1A2 P43004 1/20 0.44
▸ SLC1A1 P43005 1/20 0.44
▸ KDM4E B2RXH2 1/20 0.44
▸ USP2 O75604 1/20 0.44
▸ EGFR P00533 1/20 0.44
▸ LCK P06239 1/20 0.44
▸ FYN P06241 1/20 0.44
▸ ADORA3 P0DMS8 1/20 0.44
▸ ALOX15 P16050 1/20 0.44
▸ HTR2A P28223 1/20 0.44
▸ PTGS2 P35354 1/20 0.44
▸ RECQL P46063 1/20 0.44
▸ HIF1A Q16665 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2490445 0.90 SLC7A5 (0.57) SLC7A5HDAC8TAAR1SLC6A2
Tyrosine SCHEMBL11338508 0.90 SLC7A5 (0.60) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL1422055 0.89 SLC7A5 (0.64) SLC7A5PTGS1ALPIPKMXIAP
SCHEMBL3486841 0.89 ALPI (0.58) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL2205390 0.88 SLC7A5 (0.61) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL2284689 0.87 SLC7A5 (0.77) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL28019917 0.87 SLC7A5 (0.77) SLC7A5PTGS1ALPIPKMXIAP
Phenylalanine Methyl Ester SCHEMBL28119139 0.85 SLC7A5 (0.69) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL28049225 0.84 SLC7A5 (0.77) SLC7A5PTGS1ALPIPKMXIAP
Tyrosine SCHEMBL5699043 0.84 SLC7A5 (0.89) SLC7A5PTGS1ALPIPKMXIAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030148932-A1 Compounds that bind to p185 and methods of using the same NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-08-07 — — US claimed
WO-2003045309-A2 Peptides, peptide compositions,and methods of use in binding p 185 THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2003-06-05 — — WO claimed
US-7998924-B2 Compounds that bind to p185 and methods of using the same THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2011-08-16 — — US disclosed
US-20100311669-A1 COMPOUNDS THAT BIND TO P185 AND METHODS OF USING THE SAME NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-12-09 — — US disclosed
US-7745577-B2 Compounds that bind to P185 and methods of using the same THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2010-06-29 — — US disclosed
US-20070207086-A1 Compounds that bind to P185 and methods of using the same UNIVERSITY OF PENNSYLVANIA (US) 2007-09-06 — — US disclosed
US-7179785-B2 Compounds that bind to p185 and methods of using the same THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2007-02-20 — — US disclosed
US-20030148932-A1 Compounds that bind to p185 and methods of using the same NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-08-07 — — US disclosed
WO-2003045309-A2 Peptides, peptide compositions,and methods of use in binding p 185 THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 2003-06-05 — — WO disclosed