Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 7/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.30 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24673601 | 0.86 | KDM4E (0.38) | KDM4EDRD2EPHX1EPHX2CYP1A2 | |
| SCHEMBL15113488 | 0.83 | TSHR (0.39) | KDM4EEPHX1EPHX2TSHR | |
| SCHEMBL26228251 | 0.82 | L3MBTL1 (0.37) | KDM4EDRD2EPHX1EPHX2 | |
| SCHEMBL15113496 | 0.81 | NCF1 (0.33) | TSHR | |
| SCHEMBL25706920 | 0.80 | EPHX1 (0.38) | KDM4EEPHX1EPHX2 | |
| SCHEMBL21107507 | 0.80 | KDM4E (0.43) | KDM4EDRD2CYP1A2CYP2D6ALOX15 | |
| SCHEMBL21733145 | 0.80 | KDM4E (0.39) | KDM4EDRD2EPHX1EPHX2CYP1A2 | |
| SCHEMBL14942381 | 0.80 | KDM4E (0.42) | KDM4EDRD2EPHX1EPHX2CYP1A2 | |
| SCHEMBL24848351 | 0.79 | PRMT6 (0.35) | KDM4EEPHX1EPHX2 | |
| SCHEMBL24608220 | 0.79 | KDM4E (0.34) | KDM4ECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021133920-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-07-01 | — | — | WO | disclosed |
| WO-2020264499-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2020-12-30 | — | — | WO | disclosed |