Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.38 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.38 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18557206 | 1.00 | ALDH1A1 (0.42) | ALDH1A1LMNAMAPK1MAPTMEN1 | |
| SCHEMBL17643421 | 0.87 | EPHX2 (0.40) | ALDH1A1EPHX2EPHX1CHRNB2CHRNA3 | |
| SCHEMBL6631486 | 0.87 | EPHX2 (0.40) | ALDH1A1EPHX2EPHX1CHRNB2CHRNA3 | |
| SCHEMBL478665 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTMEN1POLB | |
| SCHEMBL12136815 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTMEN1POLB | |
| SCHEMBL4309663 | 0.81 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTMEN1POLB | |
| SCHEMBL6631511 | 0.79 | CHRNB2 (0.54) | CHRNB2CHRNA3CHRNA4CHRNB3CHRNA6 | |
| SCHEMBL25010712 | 0.79 | DPP4 (0.42) | ALDH1A1LMNAMAPK1MAPTMEN1 | |
| SCHEMBL21938965 | 0.79 | DPP4 (0.42) | ALDH1A1LMNAMAPK1MAPTMEN1 | |
| SCHEMBL2760455 | 0.79 | DPP4 (0.42) | ALDH1A1LMNAMAPK1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11464780-B2 | Pyrazolopyrimidine derivative and use thereof | SIMCERE PHARMACEUTICAL CO. LTD. (CN) | 2022-10-11 | — | — | US | disclosed |
| US-20200405725-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF | NANJING ZAIMING PHARMACEUTICAL CO., LTD. (CN) | 2020-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200405725-A1 | PYRAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF | TPMT, VHL, GOT2 | ALDH1A1 1254/4885LMNA 3027/4885MAPK1 2338/4885 |
| US-11464780-B2 | Pyrazolopyrimidine derivative and use thereof | TPMT, VHL, GOT2 | ALDH1A1 1254/4885LMNA 3027/4885MAPK1 2338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.