Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX1 | Q96LB2 | 7/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSPO | P30536 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294699 | 1.00 | MRGPRX1 (0.54) | MRGPRX1GAAL3MBTL1MAPTLMNA | |
| SCHEMBL30294316 | 0.88 | MRGPRX1 (0.56) | MRGPRX1GAAL3MBTL1MAPTLMNA | |
| SCHEMBL22853109 | 0.88 | MRGPRX1 (0.56) | MRGPRX1GAAL3MBTL1MAPTLMNA | |
| SCHEMBL22853357 | 0.87 | MAPT (0.50) | MRGPRX1MAPTLMNATSHRKMT2A | |
| SCHEMBL30294796 | 0.87 | MAPT (0.50) | MRGPRX1MAPTLMNATSHRKMT2A | |
| SCHEMBL4364443 | 0.82 | GAA (0.50) | GAAL3MBTL1MAPTLMNATSHR | |
| SCHEMBL22853031 | 0.79 | KMT2A (0.51) | MAPTLMNAKMT2AMEN1MAPK1 | |
| SCHEMBL30294853 | 0.79 | KMT2A (0.51) | MAPTLMNAKMT2AMEN1MAPK1 | |
| SCHEMBL22853397 | 0.79 | MAPT (0.49) | MRGPRX1MAPTLMNATSHRKMT2A | |
| SCHEMBL30294446 | 0.79 | LMNA (0.52) | GAAL3MBTL1MAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |