Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP3 | P05413 | 1/20 | 0.51 |
| ▸ | FABP4 | P15090 | 1/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.50 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.45 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294242 | 1.00 | FABP3 (0.51) | FABP3FABP4MPOP2RY4METAP2 | |
| SCHEMBL22853345 | 0.90 | KDM4E (0.51) | FABP3FABP4MPOP2RY4METAP2 | |
| SCHEMBL22853126 | 0.88 | MPO (0.58) | MPOAKR1C3AKR1C2DHODH | |
| SCHEMBL30294628 | 0.88 | MPO (0.58) | MPOAKR1C3AKR1C2DHODH | |
| SCHEMBL9000255 | 0.87 | FABP3 (0.61) | FABP3FABP4MPOP2RY4KEAP1 | |
| SCHEMBL30294345 | 0.85 | FABP3 (0.47) | FABP3FABP4MPOP2RY4METAP2 | |
| SCHEMBL22853159 | 0.85 | FABP3 (0.47) | FABP3FABP4MPOP2RY4METAP2 | |
| SCHEMBL22853379 | 0.85 | PKM (0.42) | PKMKDM4EALDH1A1GAAMAPT | |
| SCHEMBL30294383 | 0.85 | PKM (0.42) | PKMKDM4EALDH1A1GAAMAPT | |
| SCHEMBL30294505 | 0.81 | TAS2R14 (0.52) | MPOCLCN2AKR1C3AKR1C2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |