Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.39 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.39 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294526 | 1.00 | SORT1 (0.46) | SORT1HPGDKDM4ENTRK1NTRK2 | |
| SCHEMBL29382977 | 0.90 | SCN8A (0.47) | SORT1HPGDKDM4ENTRK1NTRK2 | |
| SCHEMBL22853425 | 0.90 | SCN8A (0.47) | SORT1HPGDKDM4ENTRK1NTRK2 | |
| SCHEMBL30294376 | 0.88 | SORT1 (0.46) | SORT1HPGDKDM4ENTRK1NTRK2 | |
| SCHEMBL22852910 | 0.88 | SORT1 (0.46) | SORT1HPGDKDM4ENTRK1NTRK2 | |
| SCHEMBL30294361 | 0.88 | SCN8A (0.47) | SORT1KDM4EDHODHRXFP1SCN8A | |
| SCHEMBL22853243 | 0.88 | SCN8A (0.47) | SORT1KDM4EDHODHRXFP1SCN8A | |
| SCHEMBL22853430 | 0.87 | SORT1 (0.45) | SORT1HPGDKDM4ENTRK1NTRK2 | |
| SCHEMBL30294432 | 0.87 | SORT1 (0.45) | SORT1HPGDKDM4ENTRK1NTRK2 | |
| SCHEMBL22853181 | 0.87 | SORT1 (0.52) | SORT1HPGDKDM4ENTRK1NTRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |