Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 6/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.38 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.38 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294432 | 1.00 | SORT1 (0.45) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL30294376 | 0.89 | SORT1 (0.46) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL22852910 | 0.89 | SORT1 (0.46) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL22853070 | 0.88 | SORT1 (0.46) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL30294869 | 0.88 | SORT1 (0.46) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL22853186 | 0.87 | SORT1 (0.46) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL30294526 | 0.87 | SORT1 (0.46) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL22853425 | 0.87 | SCN8A (0.47) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL29382977 | 0.87 | SCN8A (0.47) | SORT1NTRK1NTRK2KDM4EHPGD | |
| SCHEMBL22853494 | 0.86 | RXFP1 (0.48) | SORT1NTRK1NTRK2KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |