Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN8A | Q9UQD0 | 4/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | LIPE | Q05469 | 1/20 | 0.42 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.41 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC20A2 | Q08357 | 1/20 | 0.40 |
| ▸ | SLC20A1 | Q8WUM9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294361 | 1.00 | SCN8A (0.47) | SCN8ASORT1MAPTKDM4EMAPK1 | |
| SCHEMBL30294814 | 0.93 | SORT1 (0.43) | SCN8ASORT1MAPTKDM4EMAPK1 | |
| SCHEMBL22853196 | 0.93 | SORT1 (0.43) | SCN8ASORT1MAPTKDM4EMAPK1 | |
| SCHEMBL22853497 | 0.91 | MEN1 (0.47) | SCN8ASORT1MAPTKDM4EMAPK1 | |
| SCHEMBL30294304 | 0.91 | MEN1 (0.47) | SCN8ASORT1MAPTKDM4EMAPK1 | |
| SCHEMBL22853425 | 0.90 | SCN8A (0.47) | SCN8ASORT1KDM4ERXFP1SCN10A | |
| SCHEMBL29382977 | 0.90 | SCN8A (0.47) | SCN8ASORT1KDM4ERXFP1SCN10A | |
| SCHEMBL22853186 | 0.88 | SORT1 (0.46) | SCN8ASORT1KDM4EDHODHRXFP1 | |
| SCHEMBL30294526 | 0.88 | SORT1 (0.46) | SCN8ASORT1KDM4EDHODHRXFP1 | |
| SCHEMBL22852910 | 0.84 | SORT1 (0.46) | SCN8ASORT1MAPTKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |