Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 1/20 | 0.48 |
| ▸ | SORT1 | Q99523 | 3/20 | 0.44 |
| ▸ | DHODH | Q02127 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.40 |
| ▸ | AGBL2 | Q5U5Z8 | 1/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30294772 | 1.00 | CFTR (0.48) | CFTRSORT1DHODHLMNAGAA | |
| SCHEMBL30294399 | 0.91 | ALDH1A1 (0.50) | SORT1LMNAGAAL3MBTL1MAPK1 | |
| SCHEMBL22853368 | 0.91 | ALDH1A1 (0.50) | SORT1LMNAGAAL3MBTL1MAPK1 | |
| SCHEMBL30294484 | 0.90 | DHODH (0.46) | CFTRDHODHLMNAGAAALDH1A1 | |
| SCHEMBL22853393 | 0.90 | DHODH (0.46) | CFTRDHODHLMNAGAAALDH1A1 | |
| SCHEMBL22853174 | 0.88 | SORT1 (0.54) | SORT1DHODHLMNAALDH1A1TDP1 | |
| SCHEMBL30294412 | 0.88 | SORT1 (0.54) | SORT1DHODHLMNAALDH1A1TDP1 | |
| SCHEMBL22833312 | 0.81 | DHODH (0.56) | SORT1DHODHTAS2R14AGBL2 | |
| SCHEMBL29383420 | 0.81 | DHODH (0.56) | SORT1DHODHTAS2R14AGBL2 | |
| SCHEMBL22853203 | 0.80 | SORT1 (0.46) | SORT1DHODHGAAMAPK3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261114-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-12-30 | — | — | WO | disclosed |