Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SORT1 | Q99523 | 10/20 | 0.54 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.50 |
| ▸ | DHODH | Q02127 | 5/20 | 0.48 |
| ▸ | LIPC | P11150 | 1/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22853174 | 1.00 | SORT1 (0.54) | SORT1TAS2R14DHODHLIPCLIPG | |
| SCHEMBL29382196 | 0.91 | MKNK2 (0.47) | SORT1TAS2R14DHODHMEN1GMNN | |
| SCHEMBL22833733 | 0.91 | MKNK2 (0.47) | SORT1TAS2R14DHODHMEN1GMNN | |
| SCHEMBL22853164 | 0.90 | ALDH1A1 (0.52) | SORT1TAS2R14DHODHMEN1ALDH1A1 | |
| SCHEMBL30294847 | 0.90 | ALDH1A1 (0.52) | SORT1TAS2R14DHODHMEN1ALDH1A1 | |
| SCHEMBL22853365 | 0.88 | CFTR (0.48) | SORT1TAS2R14DHODHALDH1A1LMNA | |
| SCHEMBL30294772 | 0.88 | CFTR (0.48) | SORT1TAS2R14DHODHALDH1A1LMNA | |
| SCHEMBL22833312 | 0.87 | DHODH (0.56) | SORT1TAS2R14DHODHAGBL2HDAC6 | |
| SCHEMBL29383420 | 0.87 | DHODH (0.56) | SORT1TAS2R14DHODHAGBL2HDAC6 | |
| SCHEMBL22853093 | 0.84 | DHODH (0.47) | SORT1TAS2R14DHODHLIPCLIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2023-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230103791-A1 | 2,3-DIHYDROQUINAZOLIN COMPOUNDS AS NAV1.8 INHIBITORS | SCN8A, SCN1A, SCN1B | SORT1 3573/4885TAS2R14 1406/4885DHODH 1951/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.