SCHEMBL22853589

SCHEMBL22853589

O=C1c2ccccc2CN1c1cc(C(c2ccc(O)c(N3C(=O)c4ccccc4C3=O)c2)(C(F)(F)F)C(F)(F)F)ccc1O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 4/20 0.40
RAB9A P51151 4/20 0.40
PKM P14618 3/20 0.40
NR1H3 Q13133 3/20 0.39
NR1H2 P55055 1/20 0.39
TYMS P04818 1/20 0.35
CYP11B2 P19099 1/20 0.35
KMT2A Q03164 2/20 0.35
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
TP53 P04637 2/20 0.34
SMN1; SMN2 Q16637 2/20 0.34
MEN1 O00255 1/20 0.34
LMNA P02545 1/20 0.34
CYP2D6 P10635 1/20 0.34
CYP2C19 P33261 1/20 0.34
PGR P06401 1/20 0.34
CYP3A4 P08684 1/20 0.34
GAA P10253 1/20 0.34
NFKB1 P19838 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23133322 0.87 TYMS (0.43) NR1H3NR1H2TYMSKMT2AESR1
SCHEMBL9610064 0.81 TYMS (0.47) NR1H3NR1H2TYMSKMT2AESR1
SCHEMBL18932803 0.76 MEN1 (0.46) TYMSKMT2ASMN1; SMN2MEN1LMNA
SCHEMBL27250012 0.74 TYMS (0.44) NR1H3NR1H2TYMSKMT2AESR1
SCHEMBL27719258 0.74 ESR1 (0.41) NPC1RAB9AKMT2AESR1ESR2
SCHEMBL28636069 0.72 NPC1 (0.59) NPC1RAB9APKMCYP11B2KMT2A
SCHEMBL23373913 0.71 ESR1 (0.36) NR1H3TYMSKMT2AESR1ESR2
SCHEMBL18932780 0.71 LMNA (0.47) NPC1RAB9AKMT2ATP53MEN1
SCHEMBL18932777 0.71 MAPT (0.49) NPC1RAB9ATYMSKMT2AESR1
SCHEMBL2622758 0.70 ESR1 (0.41) NR1H3NR1H2TYMSKMT2AESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11267967-B2 Composition, electro-optic material, electro-optic device, and method for preparing electro-optic material SAMSUNG ELECTRONICS CO., LTD. (KR) 2022-03-08 US disclosed
US-20200407555-A1 COMPOSITION, ELECTRO-OPTIC MATERIAL, ELECTRO-OPTIC DEVICE, AND METHOD FOR PREPARING ELECTRO-OPTIC MATERIAL SAMSUNG ELECTRONICS CO., LTD. (KR) 2020-12-31 US disclosed