Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | PANK3 | Q9H999 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.40 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15652842 | 0.81 | MAPT (0.50) | RORCALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL26938693 | 0.81 | ALDH1A1 (0.49) | RORCALDH1A1KDM4EMAPTL3MBTL1 | |
| SCHEMBL10147276 | 0.79 | USP2 (0.54) | HRH3ALDH1A1KDM4EPANK3MAPT | |
| SCHEMBL20004338 | 0.79 | HRH3 (0.50) | HRH3ALDH1A1KDM4EPANK3MAPT | |
| SCHEMBL15187981 | 0.79 | HRH3 (0.50) | HRH3ALDH1A1KDM4EPANK3MAPT | |
| SCHEMBL20251137 | 0.78 | MAPT (0.51) | HRH3ALDH1A1KDM4EPANK3MAPT | |
| SCHEMBL17008296 | 0.77 | KDM4E (0.49) | HRH3RORCALDH1A1KDM4EMAPT | |
| SCHEMBL13929499 | 0.77 | HTR6 (0.52) | HRH3ALDH1A1KDM4EPANK3MAPT | |
| SCHEMBL10118804 | 0.77 | HRH3 (0.49) | HRH3ALDH1A1KDM4EPANK3MAPT | |
| SCHEMBL11977005 | 0.77 | HRH3 (0.52) | HRH3RORCALDH1A1KDM4EPANK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020261294-A1 | NOVEL APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS | MANKIND PHARMA LTD. (IN) | 2020-12-30 | — | — | WO | disclosed |