Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 5/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 2/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | PKM | P14618 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | APEX1 | P27695 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | SNCA | P37840 | 1/20 | 0.55 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.54 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2285475 | 1.00 | PRMT1 (0.66) | PRMT1MEN1KMT2APOLBTDP1 | |
| SCHEMBL20251148 | 0.92 | MEN1 (0.79) | PRMT1MEN1KMT2APOLBTDP1 | |
| SCHEMBL20251155 | 0.92 | MEN1 (0.79) | PRMT1MEN1KMT2APOLBTDP1 | |
| SCHEMBL1985170 | 0.92 | MAPT (0.69) | PRMT1MEN1KMT2APOLBTDP1 | |
| SCHEMBL30963829 | 0.90 | MAPT (0.72) | PRMT1MEN1KMT2APOLBTDP1 | |
| SCHEMBL158771 | 0.90 | MEN1 (0.81) | PRMT1MEN1KMT2APOLBTDP1 | |
| Ammonia Solution, Strong SCHEMBL8043061 | 0.88 | MEN1 (0.78) | PRMT1MEN1KMT2APOLBTDP1 | |
| Hydrochloric Acid SCHEMBL18953624 | 0.88 | MEN1 (0.78) | PRMT1MEN1KMT2APOLBTDP1 | |
| SCHEMBL14130013 | 0.86 | MAPT (0.68) | MEN1KMT2APOLBTDP1LMNA | |
| N-Phenylbenzamide SCHEMBL27722554 | 0.86 | MEN1 (0.74) | PRMT1MEN1KMT2APOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9688617-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-06-27 | — | — | US | disclosed |
| US-20160229794-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2016-08-11 | — | — | US | disclosed |
| US-9334231-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-05-10 | — | — | US | disclosed |
| US-20150158811-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2015-06-11 | — | — | US | disclosed |
| US-8993736-B2 | Photoreactive synthetic regulator of protein function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-31 | — | — | US | disclosed |
| US-20110207213-A1 | Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof | ENERGY, UNITED STATES DEPARTMENT OF | 2011-08-25 | — | — | US | disclosed |
| WO-2010051343-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150158811-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | PPP1R10, PPP6R1, PPP6R3 | PRMT1 1765/4885MEN1 2960/4885KMT2A 3922/4885 |
| US-20160229794-A1 | PHOTOREACTIVE SYNTHETIC REGULATOR OF PROTEIN FUNCTION AND METHODS OF USE THEREOF | PPP1R10, PPP6R1, PPP6R3 | PRMT1 1765/4885MEN1 2960/4885KMT2A 3922/4885 |
| US-20110207213-A1 | Photoreactive Synthetic Regulator of Protein Function and Methods of Use Thereof | PPP1R10, PPP6R1, PPP6R3 | PRMT1 1765/4885MEN1 2960/4885KMT2A 3922/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.