Sugi Predict

Sugi Predict / Compounds / SCHEMBL22856422

SCHEMBL22856422

SCHEMBL22856422

CCOCCOCCOCCOCCNC(=O)COC

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 3/20 0.47
▸ MEN1 O00255 1/20 0.43
▸ KMT2A Q03164 1/20 0.43
▸ TSHR P16473 4/20 0.41
▸ HPGD P15428 4/20 0.41
▸ EPHX2 P34913 2/20 0.40
▸ THRB P10828 1/20 0.39
▸ SPR P35270 1/20 0.39
▸ CASP1 P29466 1/20 0.38
▸ CASP7 P55210 1/20 0.38
▸ HSD17B10 Q99714 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ GLA P06280 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ CYP1A2 P05177 1/20 0.38
▸ CYP2C9 P11712 1/20 0.38
▸ CYP2C19 P33261 1/20 0.38
▸ MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15888695 1.00 ALDH1A1 (0.47) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL8537710 0.92 MEN1 (0.48) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL8537552 0.92 MEN1 (0.48) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL8536337 0.90 TSHR (0.45) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL25516132 0.89 ALDH1A1 (0.44) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL15888691 0.89 ALDH1A1 (0.58) ALDH1A1TSHRHPGDEPHX2CASP1
SCHEMBL14983962 0.89 ALDH1A1 (0.44) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL24508454 0.89 MEN1 (0.47) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL22606455 0.89 MEN1 (0.43) ALDH1A1MEN1KMT2ATSHRHPGD
SCHEMBL22606458 0.89 MEN1 (0.43) ALDH1A1MEN1KMT2ATSHRHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230295180-A1 PROTEIN DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20230295180-A1 PROTEIN DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-09-21 — — US disclosed
US-20230234953-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-07-27 — — US disclosed
US-20230234936-A1 COMPOUND FOR TARGETING AND DEGRADING PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF LEADINGTAC PHARMACEUTICAL (SHAOXING) CO., LTD. (CN) 2023-07-27 — — US disclosed
WO-2022125800-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2022-06-16 — — WO disclosed
WO-2020264490-A1 IRAK DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2020-12-30 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230234936-A1 COMPOUND FOR TARGETING AND DEGRADING PROTEIN, AND PREPARATION METHOD THEREFOR AND USE THEREOF IRAK4, IRAK2, IRAK1 ALDH1A1 3835/4885MEN1 3175/4885KMT2A 1513/4885
US-20230234953-A1 IRAK DEGRADERS AND USES THEREOF IRAK2, IRAK3, IRAK1 ALDH1A1 2776/4885MEN1 4055/4885KMT2A 445/4885
US-20230295180-A1 PROTEIN DEGRADERS AND USES THEREOF MDM2, CUL1, PSMG3 ALDH1A1 3843/4885MEN1 2643/4885KMT2A 1723/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.