Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 5/20 | 0.75 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | BLM | P54132 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6107273 | 0.86 | MCHR1 (1.00) | MCHR1EPHX2HDAC3HDAC4HDAC1 | |
| SCHEMBL10889965 | 0.79 | MCHR1 (0.60) | MCHR1EPHX2KCNH2POLBLMNA | |
| SCHEMBL2648713 | 0.78 | HDAC1 (0.68) | EPHX2NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL4881358 | 0.78 | HDAC1 (0.72) | EPHX2NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL9490255 | 0.78 | ALDH1A1 (0.70) | MCHR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1499450 | 0.76 | MCHR1 (0.65) | MCHR1EPHX2NR1H4HDAC3HDAC4 | |
| SCHEMBL12845484 | 0.76 | LMNA (0.72) | MCHR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8507800 | 0.76 | MCHR1 (0.73) | MCHR1EPHX2NR1H4HDAC3HDAC4 | |
| SCHEMBL13581175 | 0.76 | TRPV1 (0.79) | EPHX2NR1H4HDAC3HDAC4HDAC1 | |
| SCHEMBL2649617 | 0.75 | MCHR1 (0.53) | MCHR1EPHX2NR1H4ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003081-B2 | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation | GILEAD SCIENCES, INC. (US) | 2011-08-23 | — | — | US | claimed |
| US-7452524-B2 | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | claimed |
| US-8003081-B2 | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation | GILEAD SCIENCES, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20090004279-A1 | Method For Improvement Of Tolerance For Therapeutically Effective Agents Delivered By Inhalation | GILEAD SCIENCES, INC. | 2009-01-01 | — | — | US | disclosed |
| US-7452524-B2 | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| EP-1807123-A2 | A METHOD FOR IMPROVEMENT OF TOLERANCE FOR THERAPEUTICALLY EFFECTIVE AGENTS DELIVERED BY INHALATION | Corus Pharma Inc. (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006060027-A2 | A METHOD FOR IMPROVEMENT OF TOLERANCE FOR THERAPEUTICALLY EFFECTIVE AGENTS DELIVERED BY INHALATION | CORUS PHARMA, INC. (US) | 2006-06-08 | — | — | WO | disclosed |
| US-20060062738-A1 | Method for improvement of tolerance for therapeutically effective agents delivered by inhalation | GILEAD SCIENCES, INC. | 2006-03-23 | — | — | US | disclosed |
| WO-2005025498-A2 | SUBSTITUTED ACETANILIDES AND BENZAMIDES FOR THE TREATMENT OF ASTHMA AND PULMONARY INFLAMMATION | CORUS PHARMA (US) | 2005-03-24 | — | — | WO | disclosed |