Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.41 |
| ▸ | CA1 | P00915 | 5/20 | 0.37 |
| ▸ | CA2 | P00918 | 5/20 | 0.37 |
| ▸ | CA9 | Q16790 | 5/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA3 | P07451 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA6 | P23280 | 1/20 | 0.37 |
| ▸ | CA5A | P35218 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.37 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.36 |
| ▸ | LPL | P06858 | 4/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F11 | P03951 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22858723 | 0.87 | HIF1A (0.42) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL4166450 | 0.85 | HIF1A (0.43) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL20563063 | 0.83 | HIF1A (0.45) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL16100693 | 0.83 | HIF1A (0.39) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL2799366 | 0.82 | LIPG (0.38) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL29897650 | 0.82 | HSP90AA1 (0.43) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL30032727 | 0.81 | ALDH1A1 (0.41) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL12069299 | 0.81 | ROCK1 (0.46) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL3491328 | 0.80 | F11 (0.40) | HIF1ACA1CA2CA9CA12 | |
| SCHEMBL2031833 | 0.79 | F11 (0.39) | CA1CA2CA9CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |