Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.36 |
| ▸ | TTK | P33981 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 6/20 | 0.35 |
| ▸ | JAK1 | P23458 | 6/20 | 0.35 |
| ▸ | TYK2 | P29597 | 5/20 | 0.35 |
| ▸ | JAK3 | P52333 | 5/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.31 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29607735 | 0.85 | MAP4K1 (0.34) | MAP4K1TTKJAK2JAK1TYK2 | |
| SCHEMBL29609161 | 0.84 | MAP4K1 (0.51) | MAP4K1TTKJAK2JAK1TYK2 | |
| SCHEMBL22858746 | 0.84 | MAP4K1 (0.51) | MAP4K1TTKJAK2JAK1TYK2 | |
| SCHEMBL22859028 | 0.83 | MAP4K1 (0.41) | MAP4K1TTKJAK2JAK1TYK2 | |
| SCHEMBL22858982 | 0.82 | MAP4K1 (0.40) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24954494 | 0.81 | MAP4K1 (0.43) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24954317 | 0.79 | MAP4K1 (0.41) | MAP4K1 | |
| SCHEMBL22858885 | 0.79 | MAP4K1 (0.45) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858749 | 0.77 | MAP4K1 (0.38) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859186 | 0.75 | MAP4K1 (0.45) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |