Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24954317 | 0.88 | MAP4K1 (0.41) | MAP4K1GPR119 | |
| SCHEMBL30893070 | 0.86 | MAP4K1 (0.40) | MAP4K1HTR1AKCNH2HRH3JAK2 | |
| SCHEMBL24954367 | 0.84 | MAP4K1 (0.58) | MAP4K1HTR1AKCNH2HRH3JAK2 | |
| SCHEMBL22859043 | 0.81 | MAP4K1 (0.36) | MAP4K1HTR1AKCNH2HRH3JAK2 | |
| SCHEMBL22859064 | 0.80 | MAP4K1 (0.55) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858782 | 0.80 | MAP4K1 (0.55) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22859204 | 0.79 | MAP4K1 (0.52) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22858946 | 0.79 | MAP4K1 (0.54) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL24954379 | 0.79 | MAP4K1 (0.43) | MAP4K1ATRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24954369 | 0.78 | MAP4K1 (0.67) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023006063-A1 | PYRROLO [2, 3-b] PYRAZINE-BASED BIFUNCTIONAL COMPOUNDS AS HPK1 DEGRADERS AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2023-02-02 | — | — | WO | disclosed |